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Abstract #0830

Multiparametric evaluation of inflammation and fibrosis in a radiation-induced murine model of colitis

Sabrina Doblas1, Magaly Zappa1,2,3, Dominique Cazals-Hatem2,4, Fabien Milliat5, Philippe Garteiser1, Eric Ogier-Denis2, and Bernard E Van Beers1,3

1Laboratory of Imaging Biomarkers, CRI-UMR1149, Inserm, Paris, France, 2Laboratory of Intestinal Inflammation, CRI-UMR1149, Inserm, Paris, France, 3Department of Radiology, Beaujon University Hospital, Clichy, France, 4Department of Pathology, Beaujon University Hospital, Clichy, France, 5Research Laboratory in Radiobiology and Radiopathology, IRSN, Fontenay-aux-Roses, France

The evaluation of fibrosis severity in Crohn’s disease is essential for patient management and prognosis, albeit seldom investigated. We validated a MR approach including diffusion-weighted imaging, magnetization transfer and FAIR perfusion to distinguish between moderate and severe forms of fibrosis in a radiation-induced murine model of colitis. The presence of fibrotic tissue and its accompanying vascular alterations induced a decrease in apparent diffusion coefficient and in perfusion, and an increase in the magnetization transfer ratio. This approach could be applied for diagnosis and assessment of intestinal fibrosis in patients.

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