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Abstract #0832

MRI of whole gut transit time in newly diagnosed coeliac disease.

Carolyn Costigan1, Nina R Lewis1, Robin C Spiller1, Paul S Morgan2, Jennifer Price3, Carolina Ciacci4, Paola Iovino4, Caroline Hoad1, Penny Gowland1, and Luca Marciani1

1Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 2Medical Physics and Clinical Engineering, Nottingham University Hospitals, Queen’s Medical Centre, Nottingham, United Kingdom, 3Nottingham NHS Treatment Centre, Nottingham University Hospitals, Queen's Medical Centre Campus, Nottingham, United Kingdom, 4Department of Medicine and Surgery, Scuola Medica Salernitana Università di Salerno, Salerno, Italy

Coeliac disease (CD) is an autoimmune disease which affects 1 in 100 people. There is no cure and the only treatment is a lifelong gluten free diet. This study aims to improve our understanding of the functional motility disorder associated with CD using MRI. Whole gut transit time (WGTT), measured using MRI transit markers, was significantly delayed in the coeliac patients compared to helathy controls (p<0.04). The MRI gut transit test is quick and is acceptable to patients and could help long term monitoring and follow up, complementing existing more invasive techniques.

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