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Abstract #0873

Evaluation of task-induced δCMRO2 with a simultaneous acquisition of CBV, CBF and BOLD signals during normoxia and hypoxia conditions

Yaoyu Zhang1,2, Yayan Yin1,3, Long Qian1, Yang Fan4, Bing Wu1,4, and Jia-Ηοng Gao1,3

1Center for MRI Research, Peking University, Beijing, China, 2Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China, 3Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China, 4MR Research China, GE Healthcare, Beijing, China

Existing studies have reported various results regarding CMRO2 behaviors during hypoxia. In this study, a simultaneous acquisition of CBV, CBF and BOLD signals was implemented to evaluate task-induced δCMRO2 under both normoxia and hypoxia conditions. Of 40 subjects who completed two runs of block-designed, black-and-white checkerboard visual tasks (normoxia and hypoxia) and a CO2 challenge, we found δCMRO2 increase significantly during hypoxia. We reckon that the simultaneous acquisition technique makes it possible for all necessary data to be acquired in one run of task, thus minimizing motion and physiological artifacts caused by separate data acquisitions through task repetitions.

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