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Abstract #0890

Imaging Microscopic Background Gradient Variations in the Mouse Brain

Choong Heon Lee1, Piotr Walczak2, Lindsay K. Hill1, Youssef Zaim Wadghiri1, and Jiangyang Zhang1

1Dept. of Radiology, New York University School of Medicine, New York, NY, United States, 2Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Microstructures in biological tissues can produce susceptibility related microscopic background gradient (μBG). Mapping the spatial distributions of μBG can help us infer tissue microstructure. In this study, we reported an improved diffusion MRI based method to detect μBG and evaluated the method using a phantom as well as normal and dysmyelinated mouse brains. We found that 3D spatial variations of μBG were greater in white matter tracts than in gray matter structures. The contrast based on μBG spatial variations was able to distinguish white matter tracts in normal and dysmyelinated mouse brains. The method may be used to study myelin injury.

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