A novel machine learning model was developed using resting-state and task fMRI on healthy subjects. This study applied this novel model to clinical patients. Preliminary data on 25 patients with space-occupying brain tumors suggested our approach could accurately predict hand functional area at the individual level in patients with brain tumors, even in cases where patients had displacement of brain tissue and reorganization of brain motor functional network. Our methods implicated the great potential for clinical application of presurgical mapping.
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