Abstract #0906

Deuterium Metabolic Imaging (DMI) of Human Brain Glucose Metabolism

Henk M. De Feyter¹, Kevin L. Behar², Peter B. Brown¹, Scott McIntyre¹, Terence W. Nixon¹, Douglas L. Rothman^1,3, and Robin A. de Graaf^1,3

¹Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Department of Psychiatry, Yale University, New Haven, CT, United States, ³Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Deuterium Metabolic Imaging (DMI) is a novel approach providing high 3D spatial resolution metabolic data from both animal models and human subjects. DMI relies on ²H MRSI in combination with administration of ²H-labeled substrates. We show how DMI combined with administration of [6,6’-²H₂]-glucose can image glucose uptake and metabolism at high spatial resolution in human brain at 4T. We provide longitudinal and transverse relaxation times of ²H-labeled brain metabolites at 4T and 11.7T to support further development and optimization of DMI applications.

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