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Abstract #0906

Deuterium Metabolic Imaging (DMI) of Human Brain Glucose Metabolism

Henk M. De Feyter1, Kevin L. Behar2, Peter B. Brown1, Scott McIntyre1, Terence W. Nixon1, Douglas L. Rothman1,3, and Robin A. de Graaf1,3

1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Department of Psychiatry, Yale University, New Haven, CT, United States, 3Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Deuterium Metabolic Imaging (DMI) is a novel approach providing high 3D spatial resolution metabolic data from both animal models and human subjects. DMI relies on 2H MRSI in combination with administration of 2H-labeled substrates. We show how DMI combined with administration of [6,6’-2H2]-glucose can image glucose uptake and metabolism at high spatial resolution in human brain at 4T. We provide longitudinal and transverse relaxation times of 2H-labeled brain metabolites at 4T and 11.7T to support further development and optimization of DMI applications.

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