During the initial processes in the formation of MS lesions, myelin is immediately digested in macrophages after phacocytosis. Chemical bond breakdown in myelin basic proteins (MBP) and among lipid bilayers (LB) can increase magnetic susceptibility. Here we measure susceptibility increase in phantom experiments of MBP breakdown and myelin LB breakdown. We investigate myelin degradation in the first few weeks of MS lesion formation by performing histology on MS brain samples and by in vivo imaging of enhancing lesions in MS patients.
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