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Abstract #0932

Myelin digestion during multiple sclerosis lesion formation contributes to increase on QSM

Kofi Deh1, Gerald Ponath2, Zaki Molvi1, Gian-Carlo Toriano Parel1, Kelly M. Gillen 1, Shun Zhang1, Thanh Nguyen 1, Pascal Spincemaille1, Yinghua Ma 1, Ajay Gupta 1, Susan Gauthier 1, David Pitt2, and Yi Wang1

1Weill Cornell Medicine, New York, NY, United States, 2Yale School of Medicine, New Haven, CT, United States

During the initial processes in the formation of MS lesions, myelin is immediately digested in macrophages after phacocytosis. Chemical bond breakdown in myelin basic proteins (MBP) and among lipid bilayers (LB) can increase magnetic susceptibility. Here we measure susceptibility increase in phantom experiments of MBP breakdown and myelin LB breakdown. We investigate myelin degradation in the first few weeks of MS lesion formation by performing histology on MS brain samples and by in vivo imaging of enhancing lesions in MS patients.

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