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Abstract #0937

Highly-accelerated volumetric brain protocol using optimized Wave-CAIPI encoding

Daniel Polak1,2,3, Stephen F. Cauley2,4, Susie Y. Huang2,4,5,6, Maria Gabriela Longo2, Berkin Bilgic2,4, Esther Raithel3, Lawrence L. Wald2,4,5, and Kawin Setsompop2,4,5

1Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 2Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Department of Radiology, Massachusetts General Hospital, Boston, MA, United States

We introduce an optimized six-minute high-resolution whole-brain protocol of 3D, mainly isotropic acquisitions for T2w SPACE, FLAIR (3D), T1w MPRAGE and T2*w SWI; all acquired at 9-fold acceleration using Wave-CAIPI encoding. Design strategies were developed to optimize wave-encoding parameter selection, coil sensitivity computation, and data-driven automated gradient trajectory error estimation. We validated our exam on five volunteers on a 3T MRI scanner and achieved good SNR with negligible g-factor noise and good image contrast despite the 9-fold acceleration. Our fast high-resolution neurological exam should benefit several clinical and research applications and help mitigate patient compliance issues and motion artifacts.

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