Abstract #0937

Highly-accelerated volumetric brain protocol using optimized Wave-CAIPI encoding

Daniel Polak^1,2,3, Stephen F. Cauley^2,4, Susie Y. Huang^2,4,5,6, Maria Gabriela Longo², Berkin Bilgic^2,4, Esther Raithel³, Lawrence L. Wald^2,4,5, and Kawin Setsompop^2,4,5

¹Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ²Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Harvard Medical School, Boston, MA, United States, ⁵Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁶Department of Radiology, Massachusetts General Hospital, Boston, MA, United States

We introduce an optimized six-minute high-resolution whole-brain protocol of 3D, mainly isotropic acquisitions for T2w SPACE, FLAIR (3D), T1w MPRAGE and T2*w SWI; all acquired at 9-fold acceleration using Wave-CAIPI encoding. Design strategies were developed to optimize wave-encoding parameter selection, coil sensitivity computation, and data-driven automated gradient trajectory error estimation. We validated our exam on five volunteers on a 3T MRI scanner and achieved good SNR with negligible g-factor noise and good image contrast despite the 9-fold acceleration. Our fast high-resolution neurological exam should benefit several clinical and research applications and help mitigate patient compliance issues and motion artifacts.

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