Abstract #0967

Hyperpolarized 129Xe Gas Exchange MRI: The Transition from 1.5 to 3 Tesla

Ziyi Wang¹, Mu He², Elianna Bier³, Brian Soher⁴, Joseph Mammarappallil⁴, Sudarshan Rajagopal⁵, Yuh-Chin Huang⁶, and Bastiaan Driehuys^1,3,4

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Electrical and Computer Engineering, Duke University, Durham, NC, United States, ³Medical Physics Graduate Program, Duke University, Durham, NC, United States, ⁴Radiology, Duke University Medical Center, Durham, NC, United States, ⁵Division of Cardiology, Duke University Medical Center, Durham, NC, United States, ⁶Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, Durham, NC, United States

Hyperpolarized ¹²⁹Xe is uniquely suited to imaging pulmonary functions by virtue of its solubility and abundant chemical shifts. Previous efforts established single-breath 3D imaging of ¹²⁹Xe ventilation, barrier uptake and RBC transfer at 1.5 Tesla. As MR vendors are increasingly transitioning their multinuclear platforms to 3 Tesla, it becomes important to enable ¹²⁹Xe gas exchange MRI at higher field strengths. Here we demonstrate that by careful measurement of spectral properties and optimization of RF and readout, short T2* can be overcome, and ¹²⁹Xe gas exchange MRI with quantitative workflow is feasible and robust at 3 Tesla.

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