Amyotrophic Lateral Sclerosis (ALS) is a fatal disease, but no fully validated and clinically specific biomarkers have been identified yet. We studied the brain entropy (BEN) of ALS patients using resting state functional magnetic resonance imaging (rs-fMRI) on fifty-six ALS patients without cognitive impairments and forty-six age- and sex-matched healthy controls. We found increased low frequency entropy in SMA/SMF and increased whole frequency entropy in precuneur/PCC regions in ALS patients. The results may improved our understanding of ALS and provide new biomarkers for diagnosis of ALS.
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