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Abstract #0975

Increased brain entropy in supplementary motor area and precuneus in amyotrophic lateral sclerosis

Liqin Yang1, Yifang Bao1, Yuxin Li1, and Daoying Geng1

1Huashan Hospital, Fudan University, Shanghai, China

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease, but no fully validated and clinically specific biomarkers have been identified yet. We studied the brain entropy (BEN) of ALS patients using resting state functional magnetic resonance imaging (rs-fMRI) on fifty-six ALS patients without cognitive impairments and forty-six age- and sex-matched healthy controls. We found increased low frequency entropy in SMA/SMF and increased whole frequency entropy in precuneur/PCC regions in ALS patients. The results may improved our understanding of ALS and provide new biomarkers for diagnosis of ALS.

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