Meeting Banner
Abstract #1015

Dopamine Release and Neural Activation Differs between Control and MDD during Reward Anticipation: a Simultaneous [11C]Raclopride PET-fMRI Study

Xue Zhang1,2, Fuyixue Wang3,4, J. Paul Hamilton5, Jingyuan E. Chen1, Ian H. Gotlib6, Mehdi Khalighi7, and Gary H. Glover1

1Radiological Sciences Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, United States, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 4A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 5Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden, 6Department of Psychology, Stanford University, Palo Alto, CA, United States, 7Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The interaction between the midbrain dopaminergic system and the striatum is implicated in reward processing; it is still unknown, however, how this interaction is altered in Major Depressive Disorder (MDD). In the current study, we compared coupling of dopamine release/binding and neural activity in adults diagnosed with MDD and healthy controls (CTLs) during a monetary incentive delay (MID) task using simultaneous $$$[^{11}C]$$$Raclopride PET and fMRI. We obtained significant correlations in CTLs but not in MDD patients, indicating that the decoupling of dopaminergic system and striatum, especially nucleus accumbens, may play a vital role in the pathophysiology of MDD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here