Abstract #1023

Simultaneous quantification of T1, T2 and Apparent Diffusion Coefficient using Magnetic Resonance Fingerprinting based on Echo Planar Imaging

Benedikt Rieger¹, Mehmet Akçakaya^2,3, Lothar R. Schad¹, and Sebastian Weingärtner^2,4

¹Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, ²Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ⁴Heidelberg University, Mannheim, Germany

In this study we propose to integrate diffusion imaging into magnetic resonance fingerprinting, a method that has shown promise for time-efficient simultaneous quantification of multiple tissue parameters. The proposed sequence for quantitative T₁, T₂ and the apparent diffusion coefficient (ADC) is based on using Cartesian EPI readout. The contrast is generated using spin-echo EPI and gradient spoiling with diffusion gradients of varying moment and varying TR and TE. Joint T₁, T₂ and ADC parameter-maps acquired in phantoms are in good agreement with reference measurements and demonstrate high quality in-vivo maps, within a scan time of 28 seconds per slice.

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