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Abstract #1029

Gaze Evoked Changes in Diffusion Characteristics of Human Optic Nerve

Kenneth T Wengler1, Tao Wang2, Patricia Stefancin2, Patrick A Sibony3, Tim Q Duong2, and Xiang He2

1Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 2Radiology, Stony Brook University Hospital, Stony Brook, NY, United States, 3Ophthalmology, Stony Brook University Hospital, Stony Brook, NY, United States

Disorders of the optic nerve (ON) are both life and sight threatening. Although disorders such as papilledema and ischemic optic neuropathy cause deformation of the peripapillary basement membrane layer, earlier pathological changes to the ON may occur further away from the eye. In this study a novel zoom-RESOLVE DTI method was developed for in vivo human ON imaging. Significant changes were observed in diffusion characteristics when comparing adduction, primary position and abduction. Gaze evoked changes in diffusion characteristics have the potential to assess diseases that affect the optic nerve before manifestation of ocular anatomical changes observed in OCT.

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