Abstract #1031

U-fiber, Long-range, and Inter-limbic Tractography Comparison in Epilepsy Patients at 7 Tesla

John W Rutland¹, Rebecca E Feldman¹, Lara V Marcuse², Madeline C Fields², Bradley N Delman³, Rafael O'Halloran¹, and Priti Balchandani¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

This study measures alterations in wholebrain connectivity and connectivity of the suspected seizure onset zone (SOZ) in MRI-negative epilepsy patients. Short-range (U-fibers), long-range, and inter-limbic white matter tracts were measured independently in a group of 19 epilepsy subjects and 10 healthy controls using diffusion imaging. Relative wholebrain hypo-connectivity of both U-fibers and inter-limbic fibers was found in epilepsy subjects. Additionally, hyper-connectivity of all 3 fiber types was found in SOZ regions compared with non-SOZ regions. These findings suggest abnormal connectivity in MRI-negative patients may prove useful in SOZ localization and treatment planning.

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