Abstract #1100

Accurate Estimation of Microscopic Diffusion Anisotropy Using Multi-shell Double Diffusion Encoding

Andrada Ianus^1,2, Sune N. Jespersen^3,4, Ivana Drobnjak², and Noam Shemesh¹

¹Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ³Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark, ⁴Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Advanced diffusion MRI acquisitions, such as double diffusion encoding (DDE), have been used to provide estimates of microscopic anisotropy, and the majority of DDE studies to date have acquired data at a single b-value. This study shows in simulations and ex-vivo experiments that the D(O)DE derived microscopic anisotropy metric strongly depends on the choice of b-value and proposes a multi shell estimation scheme which provides accurate measurements.

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