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Abstract #1100

Accurate Estimation of Microscopic Diffusion Anisotropy Using Multi-shell Double Diffusion Encoding

Andrada Ianus1,2, Sune N. Jespersen3,4, Ivana Drobnjak2, and Noam Shemesh1

1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark, 4Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Advanced diffusion MRI acquisitions, such as double diffusion encoding (DDE), have been used to provide estimates of microscopic anisotropy, and the majority of DDE studies to date have acquired data at a single b-value. This study shows in simulations and ex-vivo experiments that the D(O)DE derived microscopic anisotropy metric strongly depends on the choice of b-value and proposes a multi shell estimation scheme which provides accurate measurements.

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