Abstract #1105

Differences between treated glioblastoma and metastatic brain neoplasms revealed by non-Gaussian diffusion MRI and 18F-FET-PET

Farida Grinberg^1,2, Francesco D’Amore¹, Ganna Blazhenets¹, Ezequiel Farrher¹, Karl-Josef Langen^1,3,4, and N. Jon Shah^1,2,4

¹Institute of Neuroscience and Medicine 4, Research Centre Juelich, Juelich, Germany, ²Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ³Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany, ⁴JARA - BRAIN - Translational Medicine, RWTH Aachen University, Aachen, Germany

Metastatic brain tumours constitute the majority of all brain tumours in adult population. Differentiation of metastases from primary brain tumours such as malignant gliomas may be a diagnostic problem and is important because of different treatment strategies. Recently, and advanced diffusion MRI method, diffusion kurtosis imaging, has been shown to provide information on tumour grade of cerebral gliomas. The purpose of this work was to study the potential of two non-Gaussian diffusion methods, including diffusion kurtosis imaging and gamma-distribution-function imaging, in differentiation of the brain metastases and high-grade tumours.

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