Abstract #1107

Functional MRI mapping the optogenetic activation of the lateral hypothalamus driven by an MRI-guided robotic arm (MgRA)

Yi Chen^1,2, Pais Roldán Patricia^1,2, Xuming Chen¹, Michael Frosz³, and Xin Yu^1,4

¹Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, ³The Max Planck Institute for the Science of Light, Erlangen, Germany, ⁴The Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany

A multiple degree-of-freedom robotic controlling system was developed to guide the fiber optic targeting lateral hypothalamus in the rat brain inside the high field (14.1T) MRI scanner. Optogenetic activation of the LH leads to highly reliable functional fMRI activation patterns in the LH and its projecting regions including LPO, MPA, MPOL and StA across animals. The MgRA provides a MR-compatible brain intervention strategy to target deep brain nuclei for optogenetic activation or calcium recordings with high precision and flexibility.

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