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Abstract #1109

Brain-wide functional organization of the hippocampus along the dorsoventral axis: an optogenetic fMRI study

Russell W. Chan1,2,3, Eddie C. Wong1,2, Alex T. L. Leong1,2, Xunda Wang1,2, Celia M. Dong1,2, Karim E. Hallaoui1,2, and Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, 3Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States

Hippocampus plays a prominent role in central nervous system functions. It receives convergent projections and sends reciprocal divergent projections, forming an interactive cortico-hippocampal-cortical network. However, the precise brain-wide functional organization of different hippocampal activities along dorsoventral axis remains unknown. Using optogenetic fMRI, we revealed that functional organization of low frequency hippocampal activities along dorsoventral axis exhibits a gradual change from regions mainly involved in cognition and sensory processing to regions also involved in motor control and anxiety-related behavior. Additionally, hippocampal activities generally transit from long-range propagation to downstream cortical/subcortical regions to local intra-hippocampal propagation with increasing frequencies.

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