Abstract #1119

Validation of spinal cord fMRI with LFP and spike activity in non-human primates

Tung-Lin Wu^1,2, Pai-Feng Yang^1,3, Feng Wang^1,3, Zhaoyue Shi^1,2, Arabinda Mishra^1,3, Ruiqi Wu¹, Li Min Chen^1,3, and John C Gore^1,2,3

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Stimulus-driven and resting-state fMRI BOLD signals have previously been reported in the spinal cord to delineate its functional architecture. However, validation of these resting-state findings has yet to be performed. In this study, we compared spinal fMRI results with electrophysiology (LFP and spike activity) in non-human primates and found that 1) signals elicited by stimulation occur predominantly in the ipsilateral dorsal horn and only in the appropriate segments 2) resting-state dorsal-dorsal functional connectivity is significantly greater than that in dorsal-to-intermediate-gray-matter, and 3) resting-state functional connectivity is spatially constrained to two spinal segments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.