Stimulus-driven and resting-state fMRI BOLD signals have previously been reported in the spinal cord to delineate its functional architecture. However, validation of these resting-state findings has yet to be performed. In this study, we compared spinal fMRI results with electrophysiology (LFP and spike activity) in non-human primates and found that 1) signals elicited by stimulation occur predominantly in the ipsilateral dorsal horn and only in the appropriate segments 2) resting-state dorsal-dorsal functional connectivity is significantly greater than that in dorsal-to-intermediate-gray-matter, and 3) resting-state functional connectivity is spatially constrained to two spinal segments.
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