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Abstract #1155

A Feasibility Study of Radiation Therapy Dose Escalation Guided by Spectroscopic Magnetic Resonance Imaging in Patients with Glioblastoma

Saumya S. Gurbani1,2, Eric Mellon3, Brent D. Weinberg2, Eduard Schreibmann1, Andrew A. Maudlsey4, Sulaiman Sheriff4, Peter B. Barker5, Lawrence Kleinberg6, Lee A. D. Cooper7, Hui-Kuo Shu1, and Hyunsuk Shim1,2

1Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, United States, 2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, United States, 4Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, 5Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 6Department of Radiation Oncology, The Johns Hopkins University, Baltimore, MD, United States, 7Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, United States

Glioblastoma (GBM) is a grade IV primary brain tumor with poor outcomes despite surgical resection, chemotherapy, and radiation. Often, disease will recur in regions in the penumbra of the treatment volume, hypothesized to occur because anatomic MRI does not fully capture neoplastic infiltration. Spectroscopic magnetic resonance imaging (sMRI) enables in vivo whole-brain analysis of metabolic activity, and has been shown to sensitively and specifically identify regions of non-enhancing, infiltrating tumor. We present an ongoing prospective clinical study to target metabolically active tumor identified by sMRI for a radiation boost, with the aim of improving outcome in patients with GBM.

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