In this work, the ability to accurately co-register 3D volumes reconstructed from subsets of a variable-density 3D Cartesian acquisition is shown. Accurate rigid-body motion correction was possible for undersampling factors as high as a factor of 125 in a brain imaging application employing a 32-channel head coil. This enables efficient retrospective motion correction without loss of scan efficiency and without the need for any specialized MR hardware. This approach may help reduce the incidence of failed scans due to motion, potentially leading to a reduction for the need for sedation in pediatric patients.
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