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Abstract #1197

Highly Accelerated Multi-Contrast 3D Isotropic MRI in 5 Minutes: A Feasibility Study for Multiple Sclerosis

Xiaoxiao Ma1, Xin Lou1, Hyunkyung Maeng2, Sugil Kim2,3, Suhyung Park2, Guobin Li4, Chaohong Wang4, and Jaeseok Park2

1Chinese PLA General Hospital, Beijing, China, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 3Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea, 4United Imaging Healthcare(UIH), Shanghai, China

Multiple sclerosis(MS) is a chronic disease that damages the nerves in the brain and results in multiple areas of scar tissues within the central nervous system. Multi-contrast structural MRI, which includes T1, T2, and FLAIR, has been routinely used in detecting MS lesions. Nevertheless, it is still challenging to accurately detect small MS lesions diffused over the entire brain due to the limitation of spatial resolution and long imaging time. The purpose of this work is to investigate the feasibility of achieving highly accelerated, multi-contrast 3D isotropic (~ 1.0 mm3) MRI (T1, T2, and FLAIR), which exploits sharable information across images, for detection of MS lesions over the whole brain roughly in 5 minutes.

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