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Abstract #1207

Motion-robust sub-millimeter isotropic diffusion imaging through Motion Corrected Generalized Slice Dithered Enhanced Resolution (MC-gSlider) acquisition

Fuyixue Wang1,2, Berkin Bilgic1, Zijing Dong3, Mary Katherine Manhard1, Ned Ohringer1, Bo Zhao1, Melissa Haskell1,4, Stephen F. Cauley1, Qiuyun Fan1, Thomas Witzel1, Elfar Adalsteinsson2,5, Lawrence L. Wald1,2, and Kawin Setsompop1,2

1A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 4Graduate Program in Biophysics, Harvard University, Cambridge, MA, United States, 5Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

gSlider is an SNR-efficient acquisition technique for high-resolution diffusion imaging (dMRI). However, subject motion is inevitable during long scans in high-resolution dMRI, leading to potential for artifacts and blurring. In this study, Motion Corrected gSlider (MC-gSlider) is proposed to obtain high-quality dMRI in the presence of large in-plane and through-plane motion, without use of a navigator. A motion-aware reconstruction with spatially-adaptive regularization is developed to achieve good reconstruction, even under difficult through-plane motions. MC-gSlider was demonstrated in-vivo to provide motion-robust, sub-millimeter isotropic dMRI with a motion correction rate of 2s, allowing for good reconstruction in the presence of large motions.

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