Abstract #1227

Sub-millimetric 4D Flow MR in small intracerebral aneurysms at 7 Tesla with experimental verification in upscaled 3D printed replica.

Pierre-Francois Van de Moortele¹, Mostafa Toloui¹, Omid Amili², Sean Moen³, Sebastian Schmitter^1,4, Susanne Schnell⁵, Michael Markl^5,6, Kamil Ugurbil¹, Filippo Coletti^2,7, and Bharathi Jagadeesan^3,8,9

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²Department of Aerospace Engineering and Mechanics, University of Minnesota, Minneapolis, MN, United States, ³Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States, ⁴Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, ⁵Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ⁶Department Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States, ⁷St. Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN, United States, ⁸Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁹Department of Neurology, University of Minnesota, Minneapolis, MN, United States

Asymptomatic intracerebral aneurysms of small size (<7mm) pose a difficult therapeutic challenge: left alone they may stay stable with no consequence or they may grow and/or rupture with devastating subarachnoid hemorrages. Pre-emptive treatment (surgical or endovascular) however carries non-negligible mortality and morbidity and there is no biomarker predicting these relative risk. Flow dynamics inside small aneurysms however could have a critical impact on their evolution. Here we investigate the use of 4D Flow MR to acquire submillimitric flow information in small aneurysms in vivo as well as in 3D printed up-scaled replica of actual aneurysms measured in patients.

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