Meeting Banner
Abstract #1239

Evaluating patients with Glioma using Multi-modal Hyperpolarized C-13 and H-1 Metabolic Imaging

Yan Li1, Adam Autry1, Jeremy W Gordon1, Ilwoo Park2, Duan Xu1, Susan M Chang1, Daniel Vigneron1, and Sarah J Nelson1

1University of California San Francisco, San Francisco, CA, United States, 2Chonam National University Medical School and Hospital, Chonam, Republic of Korea

Gliomas are heterogeneous and infiltrative brain tumors. Noninvasive evaluation of the extent and activity of tumor is important for making decisions about how to manage patients with glioma. In this study, we are examining the relationship between dynamic hyperpolarized C-13 data and H-1 MRSI parameters. Eleven patients with glioma were studied with both hyperpolarized [1-13C]pyruvate imaging and 3D H-1 lactate-edited MRSI. The H-1 data were affinely registered to the C-13 data, which allows voxel-by-voxel comparison. While these initial results indicate that there may be a trend towards an inverse relationship between C-13 lactate/pyruvate and steady state normalized lactate within the choline-to-NAA (CNI) lesion, further analysis is needed in a larger population of patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here