Abstract #1241

Simultaneous PET-MRI for Investigating Associations Between Bone and Cartilage Biomarkers of Knee Osteoarthritis

Hatef Mehrabian¹, Valentina Pedoia¹, Jasmine Rossi-Devries¹, Emma Bahroos¹, Dragana Savic², and Sharmila Majumdar¹

¹Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Physiology, Anatomy, Genetics, University of Oxford, Oxford, United Kingdom

Knee osteoarthritis (OA) is caused by cartilage degeneration which has been shown to be accompanied by the changes in adjacent subchondral bone. Simultaneous PET-MRI enables investigating the biomarkers of cartilage degeneration in OA with MRI (i.e. T_1ρ, T₂ and Gadolinium uptake) as well as biomarkers of bone remodeling in OA with PET (uptake of NaF tracer in bone) at the same time. PET-MRI also allows for probing the associations between different bone and cartilage markers. Voxel-wise assessment of these associations provides insight into the local correlations between different OA markers and yields comprehensive assessment of knee OA progression.

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