Abstract #1244

Unravelling bone marrow adipose tissue composition in proximal femur sub-regions through 3T Chemical Shift Encoded-MRI: differences between osteoporosis and glucocorticoid-induced osteoporosis

Dimitri MARTEL¹, Benjamin LEPORQ², Amit SAXENA³, H.Michael BELMONT³, Gabrielle TURYAN⁴, Stephen HONIG⁵, Ravinder R. REGATTE¹, and Gregory CHANG¹

¹Department of Radiology, NYU Langone Health, New York, NY, United States, ²Université de Lyon; CREATIS CNRS UMR 5220, Inserm U1206, INSA-Lyon, UCBL Lyon 1, Villeurbanne, France, ³Department of Rheumatology, NYU Langone Health, New York, NY, United States, ⁴Radiology, NYU Langone Health, New York, NY, United States, ⁵Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Health, New York, NY, United States

Osteoporosis (OP) is due to weak bone and can ultimately lead to fracture. Recent findings shows link between bone marrow adipose tissue (bMAT) composition and amount and OP. OP can be induced by drugs such as glucocorticoids resulting in glucocorticoid-induced osteoporosis (GIO) and can affect energy metabolism pathways, induce changes in bone including increased total marrow adiposity and changes in bMAT composition. The composition of bMAT in GIO has not been previously investigated. Our aim was to assess the bMAT composition of a GIO population and compare it to OP patients using 3T Chemical Shift Encoded- MRI (CSE-MRI).

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