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Abstract #1251

ZTE MRI for attenuation correction in PET/MR: performance in a large cohort of cognitive disorder patients

Maya Khalifé1, Brian Sgard2,3, Arthur Bouchut1, Brice Fernandez4, Marine Soret2, Gaspar Delso5, Marie-Odile Habert2,3, and Aurélie Kas2,3

1Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France, 2Department of Nuclear Medicine, Groupe Hospitalier Pitié-Salpêtrière C. Foix, Paris, France, 3Laboratoire d’Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, Paris, France, 4Applications and Workflow, GE Healthcare, Orsay, France, 5Applications and Workflow, GE Healthcare, Cambridge, United Kingdom

Several attenuation correction (AC) methods based on Zero Echo Time (ZTE) MRI are available in brain PET/MR. However, most of them were evaluated in healthy subjects or in patients without apparent brain disease. In this work, we investigated ZTE-AC in a 50-patient cohort imaged for cognitive disorders and we compared its performance with default atlas-AC and reference CT-based AC. The impact of the two AC methods (ZTE-AC and atlas-AC) was evaluated and compared to reference CT-AC, using a Volume of Interest (VOI) analysis and voxelwise group comparison between patients with normal cortical metabolism vs. metabolic pattern suggestive of Alzheimer’s disease.

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