Several attenuation correction (AC) methods based on Zero Echo Time (ZTE) MRI are available in brain PET/MR. However, most of them were evaluated in healthy subjects or in patients without apparent brain disease. In this work, we investigated ZTE-AC in a 50-patient cohort imaged for cognitive disorders and we compared its performance with default atlas-AC and reference CT-based AC. The impact of the two AC methods (ZTE-AC and atlas-AC) was evaluated and compared to reference CT-AC, using a Volume of Interest (VOI) analysis and voxelwise group comparison between patients with normal cortical metabolism vs. metabolic pattern suggestive of Alzheimer’s disease.
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