Abstract #1255

Simultaneous characterization of tumor cellularity and aerobic glycolysis with PET, MR and MRSI

Christian Hundshammer^1,2, Miriam Braeuer¹, Christoph Müller^3,4, Adam E. Hansen⁵, Mathias Schillmaier⁶, Stephan Düwel^1,2,7, Benedikt Feuerecker¹, Steffen J. Glaser², Axel Haase⁷, Jorge Cabello¹, Franz Schilling¹, Jan B. Hövener³, Andreas Kjaer⁵, Stephan Nekolla¹, and Schwaiger Markus¹

¹Department of Nuclear Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany, ²Department of Chemistry, Technical University Munich, Garching, Germany, ³Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁴German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, ⁵Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark, ⁶Department of Radiology, Technical University Munich, Klinikum rechts der Isar, Munich, Germany, ⁷Munich School of Bioengineering, Technical University Munich, Garching, Germany

The new paradigm in oncology to tailor patient-specific therapies triggered the invention of powerful imaging techniques to non-invasively quantify tumor biology in depth. PET/MR is an emerging new hybrid imaging modality that allows the simultaneous acquisition of high resolution anatomical, functional and metabolic information.

We established a multimodal imaging workflow on a whole-body PET/MR system to quantify tumor cellularity, glucose uptake and aerobic glycolysis. We applied this workflow on a pre-clinical breast cancer model in a longitudinal study to analyze the effect of necrosis and tumor growth on metabolic parameters and measure the correlation of glucose uptake and LDH activity.

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