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Abstract #1255

Simultaneous characterization of tumor cellularity and aerobic glycolysis with PET, MR and MRSI

Christian Hundshammer1,2, Miriam Braeuer1, Christoph Müller3,4, Adam E. Hansen5, Mathias Schillmaier6, Stephan Düwel1,2,7, Benedikt Feuerecker1, Steffen J. Glaser2, Axel Haase7, Jorge Cabello1, Franz Schilling1, Jan B. Hövener3, Andreas Kjaer5, Stephan Nekolla1, and Schwaiger Markus1

1Department of Nuclear Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany, 2Department of Chemistry, Technical University Munich, Garching, Germany, 3Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 4German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, 5Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark, 6Department of Radiology, Technical University Munich, Klinikum rechts der Isar, Munich, Germany, 7Munich School of Bioengineering, Technical University Munich, Garching, Germany

The new paradigm in oncology to tailor patient-specific therapies triggered the invention of powerful imaging techniques to non-invasively quantify tumor biology in depth. PET/MR is an emerging new hybrid imaging modality that allows the simultaneous acquisition of high resolution anatomical, functional and metabolic information.

We established a multimodal imaging workflow on a whole-body PET/MR system to quantify tumor cellularity, glucose uptake and aerobic glycolysis. We applied this workflow on a pre-clinical breast cancer model in a longitudinal study to analyze the effect of necrosis and tumor growth on metabolic parameters and measure the correlation of glucose uptake and LDH activity.

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