Abstract #1258

Correlation between APT-CEST and 18F-Choline PET in glioma at 3T

marilena rega¹, Francisco Torrealdea², Joe Hearle³, Moritz Zaiss⁴, Ana Carvalho¹, Asim Asaf¹, Shonit Punwani², Xavier Golay⁵, John Dickson¹, Anath Shankar⁶, and Harpreet Hyare⁵

¹Institute of Nuclear Medicine, UCLH, London, United Kingdom, ²Centre for Medical Imaging, UCL, london, United Kingdom, ³Medical school, UCL, london, United Kingdom, ⁴High Field Magnetic Resonance, Max Plank Institute, Tubinghen, Germany, ⁵Brain repair and Rehabilitation, UCL, London, United Kingdom, ⁶Teenage Cancer Unit, UCLH, london, United Kingdom

Chemical exchange saturation transfer MRI is emerging as a powerful diagnostic tool and has been shown to correlate with glioma tumour grade and molecular genetics. In this study, we aim to investigate whether APT signal is a non-invasive biomarker of Teenage and Young Adult glioma cell proliferation through correlation with 18F-Cho PET SUV as the gold standard. The strong positive correlation found in APT and 18F-Cho PET SUV indirectly demonstrates that APT SI may be a marker of glioma cell proliferation and further demonstrates the potential of APT in the assessment of glioma burden.

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