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Abstract #1258

Correlation between APT-CEST and 18F-Choline PET in glioma at 3T

marilena rega1, Francisco Torrealdea2, Joe Hearle3, Moritz Zaiss4, Ana Carvalho1, Asim Asaf1, Shonit Punwani2, Xavier Golay5, John Dickson1, Anath Shankar6, and Harpreet Hyare5

1Institute of Nuclear Medicine, UCLH, London, United Kingdom, 2Centre for Medical Imaging, UCL, london, United Kingdom, 3Medical school, UCL, london, United Kingdom, 4High Field Magnetic Resonance, Max Plank Institute, Tubinghen, Germany, 5Brain repair and Rehabilitation, UCL, London, United Kingdom, 6Teenage Cancer Unit, UCLH, london, United Kingdom

Chemical exchange saturation transfer MRI is emerging as a powerful diagnostic tool and has been shown to correlate with glioma tumour grade and molecular genetics. In this study, we aim to investigate whether APT signal is a non-invasive biomarker of Teenage and Young Adult glioma cell proliferation through correlation with 18F-Cho PET SUV as the gold standard. The strong positive correlation found in APT and 18F-Cho PET SUV indirectly demonstrates that APT SI may be a marker of glioma cell proliferation and further demonstrates the potential of APT in the assessment of glioma burden.

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