MARzss method is a novel method for brain metabolite T2 quantification without varying echo time. This study evaluates the feasibility of shortening the scan time of the MARzss method by more than 80% using minimum TR and two-FA measurements. Phantom and preliminary in vivo studies show that metabolite T2 quantifications using two-FA measurements agree well with T2 values obtained by the originally proposed seven-FA measurements. In addition, Monte Carlo simulations indicate that under the same total scan time, the two-FA measurements can significantly improve the precision of T2 quantification.
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