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Abstract #1306

MOSAIC - a generalized multi-channel coil combination for 1H-MRSI via interleaved calibration scans

Philipp Moser1,2, Bernhard Strasser3, Lukas Hingerl1, Michal Považan4,5, Gilbert Hangel1, Eva Heckova1, Stephan Gruber1, Siegfried Trattnig1,2, and Wolfgang Bogner1

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 4Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

The optimal combination of signals from all receive elements is a prerequisite in MRSI especially at high field (≥7T), not only for SNR-efficient acquisition, but also for good parallel imaging reconstruction [1,2]. Phantom and in vivo experiments showed superior performance of MOSAIC including higher SNR, smaller FWHM and anatomically detailed metabolic maps compared to Brown and WSDV coil combination. MOSAIC is a flexible and robust approach for efficient MRSI coil combination under challenging conditions (B0≥7T, many coil elements, no reference coil, low SNR, possible spectral artifacts, motion/instability related artifacts, 1st-order phase error), especially with an outlook on parallel-imaging non-Cartesian MRSI.

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