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Abstract #1321

Implications of magnetic susceptibility difference between grey and white matter for spectroscopy quantification at 7T.

Donghyun Hong1, Jack JA van Asten2, Seyedmorteza Rohani Rankouhi1, Jan-Willem Thielen1, and David G. Norris1,3

1Erwin L. Hahn Institute for MRI, University of Duisburg-Essen, Essen, Germany, 2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 3Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

Magnetic susceptibility differences between grey matter (GM) and white matter (WM) can potentially affect lineshapes and chemical shifts in single voxel spectroscopy. Hitherto, analytical techniques such as LCModel assumed a single lineshape per voxel. Separated GM and WM signals using multi-echo GRE image sequence in combination with literature values for the metabolite distribution between GM and WM enable to construct a realistic basis set for LCModel. With this information we can test how magnetic susceptibility induced lineshape modification affects metabolic quantification, which uses spectral prior knowledge.

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