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Abstract #1327

How does inclusion of different macromolecular baseline models affect reproducibility of 1H-FID MRSI in the brain at 7T?

Eva Heckova1, Ursel Antpusat1,2, Michal Považan3,4, Bernhard Strasser5, Gilbert Hangel1, Lukas Hingerl1, Philipp Moser1, Stephan Gruber1, Siegfried Trattnig1,6, and Wolfgang Bogner1,6

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Hamm-Lippstadt University of Applied Sciences, Hamm, Germany, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 6Christian Doppler Laboratory for Clinical Molecular Molecular MR Imaging, Vienna, Austria

The goal was to investigate how the use of different macromolecular baseline models affects both the accuracy and test-retest reproducibility of metabolite quantification for clinically attractive FID-MRSI scan with in-plane resolution of 3.4 x 3.4 mm2 and acquisition time of 5 min. We confirmed that our 1H-FID-MRSI sequence provides information about abundance and spatial distribution of several neurometabolites with high accuracy. Including the information about the macromolecular background into the quantification process does not decrease its reproducibility.

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