Current treatment and diagnosis of pain conditions are dependent on self-reported measures. The objective of this study was to establish the feasibility of determining changes in excitatory neurotransmitter concentrations (glutamate) in the anterior cingulate cortex (ACC) as an objective measure of pain using dynamic single voxel magnetic resonance spectroscopy (MRS). Glutamate levels can accurately be detected with this paradigm, although a general trend in relation to pain was not observed across subjects. This is the first study to report dynamic levels of glutamate in the ACC in relation to pain in healthy individuals using optimized MRS acquisition and processing methods.
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