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Abstract #1346

Tracking changes in glutamate using dynamic MRS in response to an acutely painful stimulus.

Jessica Archibald1,2, Erin L Macmillan3,4,5, Carina Graf2,6, Cornelia Laule2,6,7, and John L.K Kramer1,2

1Kinesiology, University of British Colombia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 3Radiology, University of British Colombia, Vancouver, BC, Canada, 4ImageTech Lab, SFU, Simon Fraser University, Vancouver, BC, Canada, 5Philips Healthcare Canada, Philips, Vancouver, BC, Canada, 6Physics and Astronomy, University of British Colombia, Vancouver, BC, Canada, 7Pathology and Laboratory Medicine, University of British Colombia, Vancouver, BC, Canada

Current treatment and diagnosis of pain conditions are dependent on self-reported measures. The objective of this study was to establish the feasibility of determining changes in excitatory neurotransmitter concentrations (glutamate) in the anterior cingulate cortex (ACC) as an objective measure of pain using dynamic single voxel magnetic resonance spectroscopy (MRS). Glutamate levels can accurately be detected with this paradigm, although a general trend in relation to pain was not observed across subjects. This is the first study to report dynamic levels of glutamate in the ACC in relation to pain in healthy individuals using optimized MRS acquisition and processing methods.

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