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Abstract #1355

7T Magnetic Resonance Spectroscopy in the Hippocampus of MRI Normal Temporal Lobe Epilepsy Patients

John Adams1,2, Simona Nikolova3,4,5, Suzan Brown6, Robert Bartha1,2, and Jorge Burneo6,7

1Department of Medical BioPhysics, University of Western Ontario, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada, 3Department of Physics and Astronomy, University of California, Irvine, CA, United States, 4Department of Neurobiology and Behavior, University of California, Irvine, CA, United States, 5Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, United States, 6Epilepsy Program, London Health Sciences Centre, London, ON, Canada, 7Department of Clinical Neurological Studies, University of Western Ontario, London, ON, Canada

The utility of magnetic resonance spectroscopy for studying temporal lobe epilepsy (TLE) has been limited by magnetic field inhomogeneities. Using a 7T head-only MR system, we have successfully measured a number of metabolites which are challenging to measure in the hippocampus, including glutamate and glutathione, and we have observed a trend suggesting a decrease in creatine between contralateral and ipsilateral hippocampi in patients with unilateral, 1.5T MRI normal TLE.

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