Abstract #1355

7T Magnetic Resonance Spectroscopy in the Hippocampus of MRI Normal Temporal Lobe Epilepsy Patients

John Adams^1,2, Simona Nikolova^3,4,5, Suzan Brown⁶, Robert Bartha^1,2, and Jorge Burneo^6,7

¹Department of Medical BioPhysics, University of Western Ontario, London, ON, Canada, ²Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada, ³Department of Physics and Astronomy, University of California, Irvine, CA, United States, ⁴Department of Neurobiology and Behavior, University of California, Irvine, CA, United States, ⁵Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, United States, ⁶Epilepsy Program, London Health Sciences Centre, London, ON, Canada, ⁷Department of Clinical Neurological Studies, University of Western Ontario, London, ON, Canada

The utility of magnetic resonance spectroscopy for studying temporal lobe epilepsy (TLE) has been limited by magnetic field inhomogeneities. Using a 7T head-only MR system, we have successfully measured a number of metabolites which are challenging to measure in the hippocampus, including glutamate and glutathione, and we have observed a trend suggesting a decrease in creatine between contralateral and ipsilateral hippocampi in patients with unilateral, 1.5T MRI normal TLE.

This abstract and the presentation materials are available to members only; a login is required.

Join Here