Abstract #1373

Associations between Osteoarthritis Molecular Biomarkers and MR-based cartilage composition and Knee Joint Morphology: Data from the Osteoarthritis Initiative

Gabby B Joseph¹, Michael C Nevitt², Charles E McCulloch², Jan Neumann¹, John A Lynch², Ursula Heilmeier¹, Nancy E Lane³, and Thomas M Link¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States, ³Department of Rheumatology, University of California, Davis, Davis, CA, United States

This study assessed the relationships of serum/urine biomarkers for osteoarthritis with MR imaging measures of joint structure and composition, using data from the Osteoarthritis Initiative (OAI). Significant positive correlations between the serum/urine biomarkers (sHA, sMMP3) and MRI cartilage T2 relaxation time measurements, compositional markers of early cartilage degeneration were observed. However, no significant associations were found with cartilage morphology or Kellgren-Lawrence (KL) grade. Therefore, serum biomarkers and cartilage T2 composition may reflect similar features of the pathophysiology of cartilage matrix degenerative disease.

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