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Abstract #1377

Analysis of the Local Associations between Morphology and Biochemical Composition of the Articular Cartilage after Anterior Cruciate Ligament Injury and Reconstructive Surgery using Voxel-Based Relaxometry

Onyekachi Ezinna Nnabue1,2, Hatef Mehrabian1, Valentina Pedoia1, Berk Norman1, Benjamin C. Ma2, and Sharmila Majumdar1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States

This study uncovered new insights on the local associations between cartilage thickness and T relaxation time (a marker of cartilage proteoglycan content). Using Voxel-based relaxometry, this study quantified the longitudinal and cross-sectional thickness changes that occur in both the ACL-injured knee and the healthy contralateral in the lateral femoral condyle, medial femoral condyle, trochlea, medial tibia, lateral tibia, and patella and examined compartment-specific associations with relaxometry at various time points.

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