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Abstract #1383

Quantitative GagCEST MRI in Juvenile Bovine Articular Cartilage Exhibit Correlations between 3T and 7T

Lauren Watkins1, Feliks Kogan2, Marianne Black3, Marc Levenston1,2,3, and Garry Gold1,2

1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Mechanical Engineering, Stanford University, Stanford, CA, United States

GagCEST is a quantitative MR technique that shows promise at 7T to specifically detect cartilage glycosaminoglycan content; however, its potential at 3T is still uncertain. This study utilizes a new optimized 3D GagCEST sequence to maximize SNR and GagCEST contrast at 3T. Comparison of GagCEST asymmetry maps obtained at 3T and 7T suggest that GagCEST can be used to distinguish zonal differences in cartilage composition at both 3T and 7T. This work demonstrates potential for whole joint GagCEST knee imaging at 3T with improved dynamic range.

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