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Abstract #1401

Measurement of skeletal muscle extraceullar volume (ECV) in the healthy thigh: determination of the time to contrast equilibrium

Alex F Goodall1, Dr David A Broadbent1, Dr Raluca B Dumitru2,3, Prof David L Buckley4, Prof Maya Buch2,3, Dr Ai Lyn Tan2,3, and Dr John D Biglands1,2

1Department of Medical Physics & Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Department of Biomedical Imaging Science, University of Leeds, Leeds, United Kingdom

Five healthy volunteers were scanned at 3 T to determine the time to contrast equilibrium in skeletal leg muscle to establish whether extracellular volume (ECV) mapping is clinically feasible for skeletal muscle (as it has proved to be for myocardium). Time to contrast equilibrium was 13 minutes, and native T1 values were validated against the literature. It was also found that the difference in measurement of ECV using the aorta compared to the femoral artery was small. It is hoped that advancements in this technique could aid in the diagnosis and treatment of scleroderma patients with muscle involvement.

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