The mdx mouse model is one of the most commonly used animal model for Duchenne muscular dystrophy (DMD). However, it has a milder phenotype compared to patients with DMD. Evidence has demonstrated the presence of genetic modifiers that lead to phenotypic variability even with an identical gene mutation in both human and animal models of muscular dystrophy. We performed multi-parametric, high resolution MRI to demonstrate severity of disease progression in dystrophic mouse models on two different genetic backgrounds.
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