Abstract #1403

MRI characterization of skeletal muscles of two dystrophic mouse models

Ravneet Singh Vohra¹, Joshua Park¹, Philip Kramer¹, David Marcinek¹, Jeffrey Chamberlain^2,3, and Donghoon Lee¹

¹Department of Radiology, University of Washington, Seattle, WA, United States, ²Department of Neurology, University of Washington, Seattle, WA, United States, ³Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Washington, Seattle, WA, United States

The mdx mouse model is one of the most commonly used animal model for Duchenne muscular dystrophy (DMD). However, it has a milder phenotype compared to patients with DMD. Evidence has demonstrated the presence of genetic modifiers that lead to phenotypic variability even with an identical gene mutation in both human and animal models of muscular dystrophy. We performed multi-parametric, high resolution MRI to demonstrate severity of disease progression in dystrophic mouse models on two different genetic backgrounds.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.