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Abstract #1403

MRI characterization of skeletal muscles of two dystrophic mouse models

Ravneet Singh Vohra1, Joshua Park1, Philip Kramer1, David Marcinek1, Jeffrey Chamberlain2,3, and Donghoon Lee1

1Department of Radiology, University of Washington, Seattle, WA, United States, 2Department of Neurology, University of Washington, Seattle, WA, United States, 3Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Washington, Seattle, WA, United States

The mdx mouse model is one of the most commonly used animal model for Duchenne muscular dystrophy (DMD). However, it has a milder phenotype compared to patients with DMD. Evidence has demonstrated the presence of genetic modifiers that lead to phenotypic variability even with an identical gene mutation in both human and animal models of muscular dystrophy. We performed multi-parametric, high resolution MRI to demonstrate severity of disease progression in dystrophic mouse models on two different genetic backgrounds.

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