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Abstract #1407

Ex vivo MRS evaluation of severe burn injury in mice shows metabolic changes in skeletal muscle

Leo L. Cheng1, Bailing Li1,2, Lindsey. A. Vandergrift1, Jiake Chai3, and Zhongcong Xie4

1Pathology, Massachusetts General Hospital, Boston, MA, United States, 2Burns and Plastic Surgery, First Affiliated Hospital of General Hospital of PLA, Beijing, China, 3Burn and Plastic surgery, First Affiliated Hospital of PLA General Hospital, Beijing, China, 4Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States

Patients of severe burn injury often suffer from sepsis, which results in multiple organ failure and prolonged metabolic derangement, leading to higher mortality. Accurate measurements of burn injury-associated metabolic changes may provide the burn clinic with quantitative tools to assess patient status. We tested the efficacy of High-Resolution Magic Angle Spinning (HRMAS) magnetic resonance spectroscopy (MRS) in evaluation of tissue metabolic changes with mouse skeletal diaphragm and gastrocnemius muscles after burn injury. HRMAS measurements indicated that IMTG and plasma FFA levels were increased after severe burn injury, with more pronounced differences detected in diaphragm muscle than in gastrocnemius muscle.

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