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Abstract #1413

Dynamic contrast enhanced MR imaging in early stage knee osteoarthritis: A test-retest repeatability study

Faezeh Sanaei Nezhad1,2, James MacKay3, Josh Kaggie3, Martin Graves3, Fiona Gilbert3, Andrew McCaskie4, Rob Janiczek5, Geoff JM Parker1,2, Alexandra R Morgan5, and Jose Ulloa1,2

1Bioxydyn, Manchester, United Kingdom, 2Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 4Department of Trauma & Orthopaedics, University of Cambridge, Cambridge, United Kingdom, 5GSK, Stevenage, United Kingdom

Dynamic contrast-enhanced MRI (DCE-MRI) has proven to be an effective method for qualitative and quantitative measurement of synovitis in the knee. Here we evaluate the test-retest repeatability of DCE-MRI measurements in the knee at 3 T. Eight patients with mild/moderate knee osteoarthritis (OA) were scanned twice, 4 weeks apart. DCE biomarkers from the extended Tofts model were measured. This is the first demonstration of the repeatability of DCE-MRI in knee OA. This evaluation provides data to enable sample size calculations for further longitudinal and interventional studies using DCE-MRI as a biomarker of inflammation in OA.

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