Abstract #1417

Elevated conversion of hyperpolarized [1-13C]pyruvate to [1-13C]lactate is not associated with tissue acidosis, as measured with hyperpolarized [13C]bicarbonate, in a murine model of rheumatoid arthritis.

Alan J. Wright¹, Zoé M. A. Husson², De-en Hu¹, Gerard Callejo², Kevin M. Brindle^1,3, and Ewan St. John Smith²

¹CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ²Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, ³Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Measurements of synovial fluid pH in patients with rheumatoid arthritis suggest acidosis can occur at inflamed joints. A widely used model of rheumatoid arthritis is produced by injecting complete Freund’s adjuvant into the hind paw of a mouse. We have investigated whether inflammation is associated with acidosis in this model using Magnetic Resonance Spectroscopic Imaging of injected hyperpolarised [1-13C]pyruvate, to detect the metabolic changes associated with inflammation, and hyperpolarised [13C]bicarbonate to measure extracellular pH. A significant increase in the [1-13C]lactate/[1-13C]pyruvate was observed throughout the inflamed tissue, but there is no apparent acidosis

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