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Abstract #1507

­MRI biomarkers for focused-ultrasound treatment of pancreatic ductal adenocarcinoma

Ezekiel Maloney1, Ravneet Vohra1, Yak-Nam Wang1, Tatiana Khokhlova1, Stella Whang1, Kayla Gravelle1, Joshua Park1, JooHa Hwang1, and Donghoon Lee1

1University of Washington, Seattle, WA, United States

Pancreatic cancer is a devastating disease with poor prognosis. Pancreatic tumor therapy has been ineffective in part because pancreatic tumors have high interstitial fluid pressure (IFP), driven by high hyaluronan concentration and a dense desmoplastic stroma that inhibit penetration of drugs into the tumor. We performed multi-parametric MRI at high resolution to non-invasively assess tumor response in a KPC mouse model to pulsed focused ultrasound treatments. T1 and T2 relaxation as well as diffusion, magnetization transfer, and chemical exchange saturation transfer methods were used to characterize the tumors before and after focused ultrasound treatment.

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