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Abstract #1531

Development of a 3D radial MP2RAGE sequence for free-breathing T1 mapping of the mouse abdomen

Thibaut L Faller1, Aurélien J Trotier1, Sylvain Miraux1, and Emeline J Ribot1

1CRMSB UMR5536, CNRS-Univ.Bordeaux, Bordeaux, France

T1 mapping could be useful to quantify the evolution of metastases over time and evaluate therapy efficiencies. The MP2RAGE sequence enables to obtain 3D T1 maps in reasonable scan time. Nevertheless, the standard sequence is too sensitive to respiratory motion, preventing its use at the abdominal level. Consequently, a 3D radial MP2RAGE sequence has been developed. The accuracy of the T1 measurements was evaluated in vitro and on the mouse brain. Then, abdominal 3D T1 maps were obtained without motion artifact while free breathing. Finally, the radial MP2RAGE sequence was used for the early detection and characterization of hepatic metastases.

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