We investigated the sensitivity of R1rho MRI to pH and macromolecular density in in vitro phantoms and in brains of volunteers to assess its suitability as an imaging modality for detecting and assessing the response of brain tumours. We find the dependence of R1rho signal on pH in the presence of macromolecules, but a lack of pH dependence in their absence. We confirm R1rho sensitivity to macromolecular density at constant pH.
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