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Abstract #1549

Effect of corrections for image distortion and gradient nonlinearity on longitudinal DTI tumor measurements in breast patients receiving neoadjuvant chemotherapy

Lisa J Wilmes1, Ek-Tsoon Tan2, Evelyn Proctor1, Wen Li1, Jessica Gibbs1, Nola Hylton1, and David C Newitt1

1University of California San Francisco, San Francisco, CA, United States, 2GE Global Research, Niskayuna, NY, United States

Diffusion weighted imaging has shown promise for assessing tumor response to treatment, but suffers from gradient nonlinearity and image distortion that may adversely affect quantitative accuracy. This work evaluates corrections for image distortion (susceptibility-induced and eddy current) and bias from gradient non-linearity (GN) on breast tumor DTI metrics prior to treatment (T0) and at an early-treatment time point (T1), in six breast cancer patients undergoing neaoadjuvnt chemotherapy. Both GN and distortion correction had significant effects on tumor ADC and FA values at T0 and T1. The addition of distortion correction also improved the alignment of DTI and DCE-MRI tumor ROIs.

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