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Abstract #1558

Investigating the streamline count required for reproducible structural connectome construction across a range of brain parcellation resolutions

Chun-Hung Yeh1, Robert Elton Smith1, Xiaoyun Liang1, Fernando Calamante1,2, and Alan Connelly1,2

1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

This study systematically investigates a fundamental question for tractogram-based connectomics research: for a given resolution of brain parcellation, how many streamlines are required for reproducible connectome construction? We incorporate state-of-the-art tractography techniques with surface parcellation schemes of multiple granularities to investigate the influence of streamline count on the connectome variability. Our results suggest that selecting an appropriate number of streamlines is crucial for global and per-edge variability of the connectome, revealing important implications for subsequent network analysis and inferences. Methods that investigate structural connectivity with different brain parcellation resolutions should benefit from the experimental workflow and outcomes of this study.

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