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Abstract #1562

Angular versus spatial resolution in tractography for deep brain stimulation in psychiatry

Luka Liebrand1,2, Guido van Wingen1,2, Damiaan Denys1,2,3, and Matthan Caan2,4,5

1Dept. of Psychiatry, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Neuroscience, Amsterdam, Netherlands, 3Netherlands Institute for Neuroscience, Amsterdam, Netherlands, 4Dept. of Radiology, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands, 5Spinoza Centre for Neuroimaging, Amsterdam, Netherlands

Deep brain stimulation of the ventral part of the anterior limb of the internal capsule (vALIC) could potentially benefit from tractography-guided targeting, since it contains two major fiber bundles. In order to develop a diffusion-weighted sequence that has the greatest bundle specificity within the vALIC, we compared tractography results from a single-shell 3T sequence with multi-shell 3T and high-resolution 7T sequences. Although the multi-shell sequence showed superior SNR, it did not allow increased bundle discernibility in the vALIC. The high-resolution sequence showed more anatomical detail, with more radially constrained tractography, and proved superior for separating the two bundles.

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